Pain - Multiple Myeloma Center for Nurses



Pain is a widespread symptom of multiple myeloma, affecting up to 80% of patients during the course of their disease.1

It can be acute or chronic, with bone-related issues (eg, lesions/fractures, spinal cord compression) being common. In fact, about 60% of myeloma patients will present initially with bone pain.1,2

Signs and Symptoms

  • Neuropathic pain usually manifests as peripheral neuropathy, and testing and treatment procedures that patients endure also, unfortunately, contribute to pain. All types of pain can cause psychological distress and detract from quality of life1
  • Pain prevention and management are a key part of patient care. Patients should be thoroughly assessed at each visit and appropriate analgesic medications prescribed and usage monitored1
  • Bisphosphonate therapy may be administered to help treat and prevent skeletal events. Preventative measures to help minimize peripheral neuropathy during treatment, such as dosing and scheduling adjustments, and subcutaneous rather than intravenous injections for some therapies, can be considered1


  1. Rome S, Noonan K, Bertolotti P, Tariman JD, Miceli T; the International Myeloma Foundation Nurse Leadership Board. Bone health, pain, and mobility: evidence-based recommendations for patients with multiple myeloma. Clin J Oncol Nurs. 2017;21(5 suppl):47-59.
  2. Brigle K, Pierre A, Finley-Oliver E, Faiman B, Tariman JD, Miceli T; International Myeloma Foundation Nurse Leadership Board. Myelosuppression, bone disease, and acute renal failure: evidence-based recommendations for oncologic emergencies. Clin J Oncol Nurs. 2017;21(5 suppl):60-76.