Hypercalcemia - Multiple Myeloma Center for Nurses



Hypercalcemia is a myeloma-defining event that affects between 30% and 40% of patients.1,2

It occurs more commonly in patients with extensive bone involvement and may exacerbate kidney dysfunction.2-4

Signs and Symptoms

  • Symptoms include extreme thirst or dehydration, frequent urination, and constipation2
  • Ongoing monitoring and appropriate treatment are key to managing hypercalcemia, which can cause patients to have seizures or slip into a coma in extreme cases5


  1. Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538-e548.
  2. Tricot G. Clinical manifestations. In: Hoffman R, Furie B, Benz EJ, McGlave P, Silberstein LE, Shattil SJ. Hematology: Basic Principles and Practice. 5th ed. New York, NY: Churchill Livingstone; 2008.
  3. Durie BGM. Patient handbook. 2018 ed. International Myeloma Foundation website. Accessed May 13, 2021. https://imf-d8-prod.s3.us-west-1.wasabisys.com/2020-06/patient-handbook.pdf
  4. Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78(1):21-33.
  5. High calcium levels or hypercalcemia. Cancer.net website. Accessed February 14, 2021. https://www.cancer.net/coping-with-cancer/physical-emotional-and-social-effects-cancer/managing-physical-side-effects/high-calcium-levels-or-hypercalcemia